therapeutic antibodies – Communicable Diseases Research

Repertoires of SARS-CoV-2 epitopes targeted by antibodies vary according to severity of COVID-19

코로나19 중증도에 따라 항체 표적 SARS-CoV-2 에피토프 레퍼토리 달라

Article

Published on 2022-12-012022-09-11
Journal: Virulence
[Category] COVID19(2023년), SARS, 진단, 치료법,

Potent monoclonal antibodies neutralize Omicron sublineages and other SARS-CoV-2 variants

Article

Published on 2022-11-012022-11-15
Journal: Cell Reports
[Category] SARS, 변종, 진단,

Evolution of Anti-SARS-CoV-2 Therapeutic Antibodies

Article

Published on 2022-08-282022-11-15
Journal: International Journal of Molecular Sciences
[Category] SARS, 변종, 진단,

SARS-CoV-2 Omicron sublineages show comparable cell entry but differential neutralization by therapeutic antibodies

SARS-CoV-2 Omicron 하위 계통은 유사한 세포 진입을 나타내지만 치료 항체에 의한 차등 중화를 나타냅니다.

Article

Published on 2022-08-102022-09-11
Journal: Cell Host & Microbe
[Category] COVID19(2023년), SARS, 변종, 진단,

Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5

SARS-CoV-2 오미크론 하위 변이체 BA.2.12.1, BA.4 및 BA.5에 의한 항체 회피

Article

Published on 2022-08-012022-09-11
Journal: Nature
[Category] COVID19(2023년), MERS, SARS, 변종, 진단,

In vitro activity of therapeutic antibodies against SARS-CoV-2 Omicron BA.1, BA.2 and BA.5

SARS-CoV-2 Omicron BA.1, BA.2 및 BA.5에 대한 치료 항체의 시험관 내 활성

Article

Published on 2022-07-232022-09-11
Journal: Scientific Reports
[Category] COVID19(2023년), SARS, 변종, 진단,

A broad and potent neutralization epitope in SARS-related coronaviruses

SARS 관련 코로나바이러스의 광범위하고 강력한 중화 에피토프

Article

Published on 2022-07-192022-09-11
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody B.1.1.529 benefit conserved conserved epitope coronavirus CR3022 cross-neutralizing cross-neutralizing antibody Effectiveness elicited epitope high potency Interaction NAbs natural infection neutralization neutralize Neutralizing antibodies neutralizing antibody omicron RBS receptor binding site reduced respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-related coronavirus SARS-related coronaviruses therapeutic therapeutic antibodies vaccination Vaccine variants variants of concern variants of concern. VOCs X-ray X-ray crystallography
[DOI] 10.1073/pnas.2205784119 PMC 바로가기 [Article Type] Article

Role of Fc Core Fucosylation in the Effector Function of IgG1 Antibodies

IgG1 항체의 이펙터 기능에서 Fc 코어 푸코실화의 역할

Review

Published on 2022-06-302022-09-12
Journal: Frontiers in Immunology
[Category] MERS, 진단,

[키워드] ADCC ADCP antibody Antigen approved B-cell Cancer Cell cellular cytotoxicity Clinical use core decrease Dengue disease severity Effect effector Efficacy ENhance fetal fucosylation function highlighting human IgG1 Fc humoral Humoral response IgG IgG Fc IgG1 IgG1 antibody immune in vitro in vivo Infection Inflammatory diseases knowledge less mAb mAbs Macrophage mechanism Modification monoclonal antibody N-glycan natural immune response natural killer NK cells parasites phagocytosis Platelet polyclonal polymorphonuclear neutrophil pregnant women Regulation reported role SARS-CoV 2 Seven shown significantly therapeutic therapeutic antibodies treat virus virus virus infection virus.
[DOI] 10.3389/fimmu.2022.929895 PMC 바로가기 [Article Type] Review

Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and Neutralization

인간 또는 동물 ACE2 매개 바이러스 진입 및 중화에 대한 우려의 SARS-CoV-2 변이체에서 스파이크 돌연변이의 영향

Article

Published on 2022-06-292022-09-11
Journal: Microbiology Spectrum
[Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Affect angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal animals antibodies antibody Antibody neutralization antibody neutralization activity Beta caused cell entry cell line cell lines circulating common strain comparable concern coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Delta determine Effect Effectiveness Efficiency Express expressing global health Health host range Human human ACE2 Impact infect infecting information mink MOST Mutation neutralization neutralizing antibody Neutralizing titer neutralizing titers nine omicron Omicron variant over pandemic parental Protein pseudovirus pseudoviruses public policy reduced respiratory reveal S protein S proteins SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutation SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus sera several variant several variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown significantly socioeconomics spike spike mutations Spread Substitution substitutions Support susceptible tested the S protein the SARS-CoV-2 the SARS-CoV-2 virus therapeutic therapeutic antibodies Transmissibility Transmission Vaccine variant variants variants of concern variety Viral viral cell viral entry viral neutralization virulence virus virus entry virus replication Virus replication. VoC VOCs zoonotic
[DOI] 10.1128/spectrum.01789-21 PMC 바로가기 [Article Type] Article

An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo

조작된 ACE2 미끼는 SARS-CoV-2 Omicron 변이체를 중화하고 생체 내 감염으로부터 보호합니다.

Article

Published on 2022-06-222022-09-11
Journal: Science Translational Medicine
[Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제,

[키워드] ACE2 Alpha alpha and delta variants Analysis analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies B.1.1.529 BNT162b2 breakthrough infections Casirivimab chimeric Complete conserved conserved region contributed convalescent serum deep delta variant Delta variants demonstrated dose drugs effective enzyme escape escaped evade exhibited Frequency hamster hamsters human ACE2 Imdevimab immunized in vivo individual Infection multiple mutation multiple mutations Mutation N-terminal domain neutralization neutralization titer neutralize neutralized of BNT162b2 omicron parental prevented pseudo-virus raising Receptor binding domain sarbecovirus SARS-CoV-2 variant SARS-CoV-2 variants sensitivity serum serum sample serum samples Sotrovimab Spike protein Spike proteins target the SARS-CoV-2 the spike protein theory therapeutic therapeutic antibodies therapeutic effect transgenic mice vaccination Vaccines variant variants Viral viral mutation virus virus-neutralizing Wuhan strain
[DOI] 10.1126/scitranslmed.abn7737 PMC 바로가기 [Article Type] Article